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Publication : Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein.

First Author  Gaucher EA Year  2003
Journal  Genetics Volume  163
Issue  4 Pages  1549-53
PubMed ID  12702697 Mgi Jnum  J:83148
Mgi Id  MGI:2657075 Doi  10.1093/genetics/163.4.1549
Citation  Gaucher EA, et al. (2003) Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics 163(4):1549-53
abstractText  The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.
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