First Author | Kitani T | Year | 2003 |
Journal | FEBS Lett | Volume | 544 |
Issue | 1-3 | Pages | 74-8 |
PubMed ID | 12782293 | Mgi Jnum | J:83764 |
Mgi Id | MGI:2663535 | Doi | 10.1016/s0014-5793(03)00476-9 |
Citation | Kitani T, et al. (2003) Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. FEBS Lett 544(1-3):74-8 |
abstractText | A cDNA encoding the homolog of the human pre-B-cell colony-enhancing factor (PBEF), a cytokine-like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC-12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC-12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so-called PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. |