| First Author | Lee SW | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 5 | Pages | 2456-60 |
| PubMed ID | 12594270 | Mgi Jnum | J:81986 |
| Mgi Id | MGI:2450483 | Doi | 10.4049/jimmunol.170.5.2456 |
| Citation | Lee SW, et al. (2003) Inhibition of TCR-induced CD8 T cell death by IL-12: regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12. J Immunol 170(5):2456-60 |
| abstractText | In this study we demonstrate the anti-apoptotic effect of IL-12 and its underlying mechanism in CD8 T cells. The prolonged stimulation of CD8 T cells with anti-CD3 alone caused apoptosis mediated by Fas and the caspase signaling pathway. However, costimulation with IL-12 significantly prevented anti-CD3-induced apoptosis of CD8 T cells. IL-12 decreased the number of Fas ligand-positive CD8 T cells and inhibited the activation of caspase-8 and caspase-3. In addition, IL-12 up-regulated cellular FLIPs but not Bcl-2 family proteins or cellular inhibitor of apoptosis proteins. These data suggest that IL-12 provides survival signals to CD8 T cells by down-regulating Fas ligand and up-regulating cellular FLIPs, followed by inhibiting caspase activation, which implies a role for IL-12 in peripheral responses of CD8 T cells in vivo. |
