| First Author | Maitra R | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 303 |
| Issue | 3 | Pages | 842-7 |
| PubMed ID | 12670487 | Mgi Jnum | J:83145 |
| Mgi Id | MGI:2657072 | Doi | 10.1016/s0006-291x(03)00445-5 |
| Citation | Maitra R, et al. (2003) Cloning, molecular characterization, and expression analysis of Copine 8. Biochem Biophys Res Commun 303(3):842-7 |
| abstractText | Copines are ubiquitously expressed, phospholipid-binding proteins that have been conserved through evolution. In this paper, we report the cloning and molecular characterization of a new member of the Copine family, Copine 8. This gene has been isolated and characterized using a combination of bioinformatic and experimental approaches. Using an algorithm to cluster ESTs (expressed sequence tags) that are available through the public 'GoldenPath' database, Copine 8 was initially identified as a gene predominantly expressed in prostate and testis. Cloning and molecular analysis revealed that this gene is expressed in low-levels in most tissues examined. Two different isoforms of this gene have been isolated. Strongest expression of Copine 8 mRNA is seen in the prostate, heart, and brain. Taken together, this data suggest that Copine 8 may have an important role to play in prostate regulation and development. |
