| First Author | Van Mater D | Year | 2003 |
| Journal | Genes Dev | Volume | 17 |
| Issue | 10 | Pages | 1219-24 |
| PubMed ID | 12756226 | Mgi Jnum | J:83386 |
| Mgi Id | MGI:2661339 | Doi | 10.1101/gad.1076103 |
| Citation | Van Mater D, et al. (2003) Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev 17(10):1219-24 |
| abstractText | Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of beta-catenin in the skin. Chronic activation of beta-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of beta-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition. |
