| First Author | Molinari M | Year | 2003 |
| Journal | Science | Volume | 299 |
| Issue | 5611 | Pages | 1397-400 |
| PubMed ID | 12610306 | Mgi Jnum | J:85543 |
| Mgi Id | MGI:2675581 | Doi | 10.1126/science.1079474 |
| Citation | Molinari M, et al. (2003) Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. Science 299(5611):1397-400 |
| abstractText | The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum-associated degradation (ERAD) are poorly defined. Here the alpha-mannosidase I-like protein EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. EDEM overexpression resulted in faster release of folding-incompetent proteins from the calnexin cycle and earlier onset of degradation, whereas EDEM down-regulation prolonged folding attempts and delayed ERAD. Up-regulation of EDEM during ER stress may promote cell recovery by clearing the calnexin cycle and by accelerating ERAD of terminally misfolded polypeptides. |
