| First Author | Calandra T | Year | 2003 |
| Journal | Nat Rev Immunol | Volume | 3 |
| Issue | 10 | Pages | 791-800 |
| PubMed ID | 14502271 | Mgi Jnum | J:86137 |
| Mgi Id | MGI:2678861 | Doi | 10.1038/nri1200 |
| Citation | Calandra T, et al. (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3(10):791-800 |
| abstractText | For more than a quarter of a century, macrophage migration inhibitory factor (MIF) has been a mysterious cytokine. In recent years, MIF has assumed an important role as a pivotal regulator of innate immunity. MIF is an integral component of the host antimicrobial alarm system and stress response that promotes the pro-inflammatory functions of immune cells. A rapidly increasing amount of literature indicates that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune diseases, suggesting that MIF-directed therapies might offer new treatment opportunities for human diseases in the future. |
