| First Author | Hashemolhosseini S | Year | 2003 |
| Journal | FEBS Lett | Volume | 553 |
| Issue | 3 | Pages | 315-20 |
| PubMed ID | 14572643 | Mgi Jnum | J:86142 |
| Mgi Id | MGI:2678869 | Doi | 10.1016/s0014-5793(03)01037-8 |
| Citation | Hashemolhosseini S, et al. (2003) Structural requirements for nuclear localization of GCMa/Gcm-1. FEBS Lett 553(3):315-20 |
| abstractText | GCM proteins constitute a small transcription factor family. Nuclear localization of Drosophila GCM is mediated by a typical bipartite nuclear localization sequence (NLS) close to the DNA-binding GCM domain. Here, we have analyzed nuclear localization of the mammalian GCM proteins. Whereas GCMb/Gcm-2 contained a classical bipartite NLS, nuclear localization of GCMa/Gcm-1 was mediated by two regions without resemblance to known NLS, one corresponding to the amino-terminal part of the GCM domain, the second defined as a tyrosine-and-proline-rich carboxy-terminal region. Nuclear import was counteracted by an amino-terminal nuclear export activity. This complex regulation of subcellular localization has important implications for GCMa/Gcm-1 function. |
