| First Author | Zha J | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 319 |
| Issue | 2 | Pages | 298-303 |
| PubMed ID | 15178406 | Mgi Jnum | J:90457 |
| Mgi Id | MGI:3043893 | Doi | 10.1016/j.bbrc.2004.04.194 |
| Citation | Zha J, et al. (2004) RIP5 is a RIP-homologous inducer of cell death. Biochem Biophys Res Commun 319(2):298-303 |
| abstractText | Members of the RIP serine/threonine kinase family are involved in activation of NF-kappaB, JNK, and p38, and induction of apoptosis. Here we report the identification of a novel RIP-homologous protein designated as RIP5. The C-terminus of RIP5 contains a kinase domain, which is mostly homologous with the kinase domain of RIP. RIP5 also contains a large unconserved N-terminal domain. Overexpression of RIP5 induces cell death with characteristic apoptotic morphology. Overexpression of RIP5 also induces DNA fragmentation and this is blocked by the caspase inhibitor crmA. However, RIP5-induced apoptotic morphology is not blocked by crmA. These findings suggest that RIP5 may induce both caspase-dependent apoptosis and caspase-independent cell death. |
