| First Author | Samstein B | Year | 2004 |
| Journal | Transplantation | Volume | 77 |
| Issue | 3 | Pages | 475-7 |
| PubMed ID | 14966433 | Mgi Jnum | J:88336 |
| Mgi Id | MGI:3032822 | Doi | 10.1097/01.TP.0000110792.38434.F4 |
| Citation | Samstein B, et al. (2004) Toll-like receptor-4 and allograft responses. Transplantation 77(3):475-7 |
| abstractText | Signaling through toll-like receptors (TLRs) is believed to be the critical first step in the activation of antigen presenting cells and the initiation of adaptive immune responses. Of these receptors, TLR-4 particularly recognizes endogenous agonists and may be important for allograft responses. We tested this concept using mice with defective function and structure of TLR-4 as recipients of grafts across major and minor histocompatibility barriers. The kinetics of rejection was the same in mutant mice and wild-type controls. Our results highlight an important difference between alloimmune and conventional immune responses. |
