| First Author | Hedelund L | Year | 2004 |
| Journal | Lasers Surg Med | Volume | 35 |
| Issue | 1 | Pages | 58-61 |
| PubMed ID | 15278929 | Mgi Jnum | J:92126 |
| Mgi Id | MGI:3051808 | Doi | 10.1002/lsm.20067 |
| Citation | Hedelund L, et al. (2004) CO(2) laser resurfacing and photocarcinogenesis: An experimental study. Lasers Surg Med 35(1):58-61 |
| abstractText | BACKGROUND AND OBJECTIVES: To examine whether carbon dioxide (CO(2)) laser treatment has a carcinogenic potential or may influence ultraviolet (UV)-induced carcinogenesis. STUDY DESIGN/MATERIALS AND METHODS: Hairless mice (n = 211) were treated with a Sharplan CO(2) laser with FeatherTouch scanner. Simulated solar irradiations were administrated either pre-operatively or pre- and post-operatively. Weekly clinical assessments of skin tumors were performed blinded during the entire observation period of 12 months. RESULTS: No tumors appeared (a) in mice just treated with CO(2) laser, (b) in mice exposed to UV irradiation only before CO(2) laser treatment or (c) in untreated control mice. Tumors developed in CO(2) laser treated mice that were exposed to UV-irradiation both pre- and post-operatively and in UV-irradiated control mice. The time to first, second, and third tumors ranged from 18 to 20 weeks and no significant differences were demonstrated. CONCLUSIONS: CO(2) laser treatment does not have a carcinogenic potential in itself, nor does CO(2) laser treatment influence UV-induced carcinogenesis. Lasers Surg. Med. 35:58-61, 2004. Copyright 2004 Wiley-Liss, Inc. |
