| First Author | Boisvert J | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 6 | Pages | 3647-52 |
| PubMed ID | 15356109 | Mgi Jnum | J:92755 |
| Mgi Id | MGI:3054474 | Doi | 10.4049/jimmunol.173.6.3647 |
| Citation | Boisvert J, et al. (2004) Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol 173(6):3647-52 |
| abstractText | The maintenance of tolerance is likely to rely on the ability of a T cell to polarize surface molecules providing 'help' to only specific APCs. The formation of a mature immunological synapse leads to concentration of the TCR at the APC interface. In this study, we show that the CD40-CD154 receptor-ligand pair is also highly concentrated into a central region of the synapse on mouse lymphocytes only after the formation of the TCR/CD3 c-SMAC. Concentration of this ligand was strictly dependent on TCR recognition, the binding of ICAM-1 to T cell integrins and the presence of an intact cytoskeleton in the T cells. This may provide a novel explanation for the specificity of T cell help directing the help signal to the site of Ag receptor signal. It may also serve as a site for these molecular aggregates to coassociate and/or internalize alongside other signaling receptors. |
