| First Author | Harrison M | Year | 2004 |
| Journal | Trends Mol Med | Volume | 10 |
| Issue | 8 | Pages | 359-61 |
| PubMed ID | 15310454 | Mgi Jnum | J:92900 |
| Mgi Id | MGI:3054708 | Doi | 10.1016/j.molmed.2004.06.010 |
| Citation | Harrison M, et al. (2004) Wip1-deficient mice are resistant to common cancer genes. Trends Mol Med 10(8):359-61 |
| abstractText | PPM1D encodes WIP1, a serine-threonine phosphatase that had previously been shown to be the driver oncogene of a 17q23 amplicon that is present in approximately 15% of human breast tumors. However, it is unknown whether it has any role in the remaining 85% of breast tumors. A recent study using Wip1-deficient mice revealed that blocking its function significantly impaired RAS and ERBB2-induced breast tumor formation, suggesting that the inhibition of Wip1 could be a broad-spectrum treatment for breast cancer. However, because of the structure of Wip1, the development of small molecule inhibitors is a significant challenge. |
