| First Author | Endo Y | Year | 2004 |
| Journal | Genomics | Volume | 84 |
| Issue | 4 | Pages | 737-44 |
| PubMed ID | 15475251 | Mgi Jnum | J:93198 |
| Mgi Id | MGI:3056225 | Doi | 10.1016/j.ygeno.2004.07.006 |
| Citation | Endo Y, et al. (2004) Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. Genomics 84(4):737-44 |
| abstractText | Ficolin is a collagenous lectin which plays a crucial role in innate immunity. Three and two ficolins have been identified in human and mice, respectively. To identify the mouse homologue of human H-ficolin and to elucidate the orthology between mouse ficolins A/B and human L-/M-ficolins, the gene structures were explored. The mouse homologue of the H-ficolin gene was identified as a pseudogene on chromosome 4. The mouse ficolin A gene was located far from the ficolin B gene on chromosome 2, whereas the human L-ficolin and M-ficolin genes were close in the region homologous to the ficolin B locus. Together with the exon-intron structures and the phylogenetic tree, these results suggest that ficolin B is the mouse orthologue of M-ficolin and that the genes encoding serum-type ficolins, ficolin A and L-ficolin, were generated independently from the ficolin B/M-ficolin lineage each in mice and primates. |
