| First Author | Callahan CA | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 22 | Pages | 2724-9 |
| PubMed ID | 15545630 | Mgi Jnum | J:94048 |
| Mgi Id | MGI:3510573 | Doi | 10.1101/gad.1221804 |
| Citation | Callahan CA, et al. (2004) MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev 18(22):2724-9 |
| abstractText | Sonic hedgehog (Shh) signaling plays a critical role during development and carcinogenesis. While Gli family members govern the transcriptional output of Shh signaling, little is known how Gli-mediated transcriptional activity is regulated. Here we identify the actin-binding protein Missing in Metastasis (MIM) as a new Shh-responsive gene. Together, Gli1 and MIM recapitulate Shh-mediated epidermal proliferation and invasion in regenerated human skin. MIM is part of a Gli/Suppressor of Fused complex and potentiates Gli-dependent transcription using domains distinct from those used for monomeric actin binding. These data define MIM as both a Shh-responsive gene and a new member of the pathway that modulates Gli responses during growth and tumorigenesis. |
