| First Author | Faria TN | Year | 1991 |
| Journal | Biol Reprod | Volume | 44 |
| Issue | 2 | Pages | 327-31 |
| PubMed ID | 2009333 | Mgi Jnum | J:94252 |
| Mgi Id | MGI:3511709 | Doi | 10.1095/biolreprod44.2.327 |
| Citation | Faria TN, et al. (1991) Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta. Biol Reprod 44(2):327-31 |
| abstractText | The purpose of this investigation was to identify the cellular origin of placental lactogen-I (PL-I) expression in the mouse placenta and to cytologically define the transition from PL-I to PL-II expression during gestation. PL-I mRNA expression was assessed by in situ hybridization, and expression of PL-I and PL-II protein was determined by immunocytochemical analysis. PL-I mRNA and protein were localized to trophoblast giant cells. Trophoblast giant cells ceased producing PL-I at midgestation and began expressing PL-II. PL-I immunoreactivity was present in trophoblast giant cells on Days 9 and 10 of gestation but was not detectable in trophoblast giant cells on Day 11 of gestation. Immunoreactive PL-II-producing giant cells were detected first on Day 10 of gestation, continuing on Day 11 of gestation. Expression of PL-I and PL-II signals a significant functional transition in trophoblast giant cells of the developing mouse placenta. |
