| First Author | Chen SC | Year | 2004 |
| Journal | Blood | Volume | 104 |
| Issue | 10 | Pages | 3233-42 |
| PubMed ID | 15198951 | Mgi Jnum | J:94899 |
| Mgi Id | MGI:3522062 | Doi | 10.1182/blood-2003-05-1679 |
| Citation | Chen SC, et al. (2004) Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells. Blood 104(10):3233-42 |
| abstractText | Increasing evidence has shown that death signaling in T cells is regulated in a complicated way. Molecules other than death receptors can also trigger T-cell death. Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classic cell death, PSGL-1-mediated T-cell death is caspase independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1-mediated T-cell death. Collectively, this study demonstrates a novel role for PSGL-1 in controlling activated T-cell death and, thus, advances our understanding of immune regulation. |
