| First Author | Tanikawa J | Year | 2004 |
| Journal | J Biol Chem | Volume | 279 |
| Issue | 53 | Pages | 55393-400 |
| PubMed ID | 15509555 | Mgi Jnum | J:95035 |
| Mgi Id | MGI:3522540 | Doi | 10.1074/jbc.M411658200 |
| Citation | Tanikawa J, et al. (2004) p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A. J Biol Chem 279(53):55393-400 |
| abstractText | p53 is known to repress transcription of a number of genes, but the mechanism of p53 recruitment to these target genes is unknown. The c-myb proto-oncogene product (c-Myb) positively regulates proliferation of immature hematopoietic cells, whereas p53 blocks cell cycle progression. Here, we demonstrate that p53 inhibits c-Myb-induced transcription and transformation by directly binding to c-Myb. The ability of c-Myb to maintain the undifferentiated state of M1 cells was also suppressed by p53. p53 did not affect the ability of c-Myb to bind to DNA but formed a ternary complex with the corepressor mSin3A and c-Myb. Thus, p53 antagonizes c-Myb by recruiting mSin3A to down-regulate specific Myb target genes. |
