| First Author | Herre J | Year | 2004 |
| Journal | Blood | Volume | 104 |
| Issue | 13 | Pages | 4038-45 |
| PubMed ID | 15304394 | Mgi Jnum | J:95294 |
| Mgi Id | MGI:3525792 | Doi | 10.1182/blood-2004-03-1140 |
| Citation | Herre J, et al. (2004) Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 104(13):4038-45 |
| abstractText | The phagocytosis of pathogens is a critical event in host defense, not only for clearance of the invading microorganism, but also for the subsequent immune response. We have examined Dectin-1, a proinflammatory nonopsonic receptor for beta-glucans, and show that it mediates the internalization of beta-glucan-bearing ligands, including yeast particles. Although requiring tyrosine phosphorylation and the cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM)-like motif, uptake mediated by Dectin-1 was different from any previously reported phagocytic receptor and was not dependent on Syk-kinase in macrophages. Furthermore, intracellular trafficking of this receptor was influenced by the nature of the beta-glucan ligand, which has significance for the biologic activity of these immunomodulatory carbohydrates. |
