| First Author | Lang G | Year | 2005 |
| Journal | Oncogene | Volume | 24 |
| Issue | 8 | Pages | 1375-84 |
| PubMed ID | 15608679 | Mgi Jnum | J:96095 |
| Mgi Id | MGI:3529396 | Doi | 10.1038/sj.onc.1208301 |
| Citation | Lang G, et al. (2005) Myb proteins regulate the expression of diverse target genes. Oncogene 24(8):1375-84 |
| abstractText | Hematopoiesis, the process by which mature blood cells arise, is controlled by multiple transcription factors, which act in stage- and lineage-specific complexes. It is a major goal to elucidate the genes regulated by these transcription factors, in order to obtain a full understanding of the process and its malignant counterpart, leukemia. Myb family transcription factors play a central role in hematopoiesis. To identify new Myb family target genes, we have used an inducible dominant-negative protein for a subtraction cloning protocol in a model cell system (FDCP-Mix) with many characteristics of normal hematopoiesis. We present here a novel group of 29 validated Myb family target genes of diverse functions. |
