| First Author | Fukumoto A | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 5 | Pages | 1047-54 |
| PubMed ID | 15710389 | Mgi Jnum | J:96148 |
| Mgi Id | MGI:3529614 | Doi | 10.1016/j.febslet.2004.12.076 |
| Citation | Fukumoto A, et al. (2005) Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation. FEBS Lett 579(5):1047-54 |
| abstractText | Jab1 interacts with a variety of cell cycle and signal transduction regulators to control cell proliferation, differentiation, and tumorigenesis. In this study, we employed a non-denaturing gel electrophoresis method to separate different Jab1-containing complexes, the COP9 signalosome complex and the small Jab1-containing subcomplex. The formation of the small Jab1 complex was dependent on a low cell density and anchorage to a solid support, and enhanced during the early G1 phase of the cell cycle, which was abrogated in ras-transformed cells. The small Jab1-containing subcomplex may be a novel mediator of anchorage and cell-cell contact-dependent signal transduction. |
