| First Author | de La Coste A | Year | 2005 |
| Journal | J Immunol | Volume | 174 |
| Issue | 5 | Pages | 2730-7 |
| PubMed ID | 15728481 | Mgi Jnum | J:97740 |
| Mgi Id | MGI:3576192 | Doi | 10.4049/jimmunol.174.5.2730 |
| Citation | de La Coste A, et al. (2005) In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects. J Immunol 174(5):2730-7 |
| abstractText | The role of Notch signaling in T cell commitment during lymphoid development is well established. However, the identity of the ligand that triggers this critical signal in vivo is still unclear. By overexpressing Delta-1 and Delta-4 ligands in the hemopoietic cells of athymic nu/nu host mice, we demonstrate that, in vivo and in the absence of a thymus, Delta-1 or Delta-4 expression is sufficient to promote T cell development from the most immature progenitor stages to complete maturation of both CD8(+) and CD4(+) alphabeta T cells. The mature T cells developing in a Delta-1- or Delta-4-enriched environment express a diverse TCR repertoire, are able to proliferate upon in vitro TCR stimulation, but show different profiles of cytokine production after in vitro anti-CD3 stimulation. |
