| First Author | Ribeiro OG | Year | 2005 |
| Journal | Exp Lung Res | Volume | 31 |
| Issue | 1 | Pages | 105-16 |
| PubMed ID | 15765921 | Mgi Jnum | J:97847 |
| Mgi Id | MGI:3576524 | Doi | 10.1080/01902140490495237 |
| Citation | Ribeiro OG, et al. (2005) Genetic selection for high acute inflammatory response confers resistance to lung carcinogenesis in the mouse. Exp Lung Res 31(1):105-16 |
| abstractText | Mice selected for a high acute inflammatory response (AIRmax) are resistant to chemically induced lung tumorigenesis, whereas the low responders (AIRmin) are susceptible. In urethane-treated mice, anti-inflammatory drugs increased the tumor incidence in AIRmax but not AIRmin mice, and an inverse correlation (P<.001) between the degree of acute inflammatory response (AIR) and lung tumorigenesis was found in an F2 (AIRmax x AIRmin) intercross population. The results provide evidence for the involvement of lung tumor modifier loci in AIR regulation and implicate AIR quantitative trait loci in the inherited predisposition to lung cancer. |
