| First Author | Latham KE | Year | 2005 |
| Journal | Trends Genet | Volume | 21 |
| Issue | 2 | Pages | 120-7 |
| PubMed ID | 15661358 | Mgi Jnum | J:98120 |
| Mgi Id | MGI:3577166 | Doi | 10.1016/j.tig.2004.12.003 |
| Citation | Latham KE (2005) X chromosome imprinting and inactivation in preimplantation mammalian embryos. Trends Genet 21(2):120-7 |
| abstractText | Dosage compensation for the mammalian X chromosome involves the silencing of one X chromosome to achieve equal X-linked gene expression between males and females. X chromosome inactivation (XCI) is controlled by a complex set of genetic elements located in a region known as the X chromosome inactivation center, and is regulated by a combination of genomic imprinting, cell lineage-dependent erasure of imprinting, an unidentified mechanism of X chromosome counting, an incompletely understood means of selection of one X chromosome for inactivation and developmentally regulated changes in X chromosome chromatin. A detailed understanding of when and how these components of XCI occur is essential for elucidating the operative mechanisms. A model accounting for early events related to XCI, including observations in uniparental and aneuploid embryos, is presented. |
