| First Author | Kanemoto S | Year | 2005 |
| Journal | Biochem Biophys Res Commun | Volume | 331 |
| Issue | 4 | Pages | 1146-53 |
| PubMed ID | 15882996 | Mgi Jnum | J:98283 |
| Mgi Id | MGI:3577797 | Doi | 10.1016/j.bbrc.2005.04.039 |
| Citation | Kanemoto S, et al. (2005) XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress. Biochem Biophys Res Commun 331(4):1146-1153 |
| abstractText | In mammals, the transmembrane protein kinase/endoribonuclease IRE1 is activated by endoplasmic reticulum stress and subsequently processes XBP1 mRNA to generate an active form of XBP1 protein. The spliced form of XBP1 protein acts as a transcription factor and induces the expression of ER-resident molecular chaperones. However, the mechanism for how XBP1 promotes the transcription of its target genes as well as the cis-acting elements for XBP1 during ER stress has been unclear. Recently, it was demonstrated that the expression of MDG1/ERdj4, a member of the DnaJ family, is regulated by the IRE1-XBP1 pathway. In the present report, we investigated the regulatory mechanisms of MDG1/ERdj4 gene expression by XBP1. We identified a cis-acting element in the MDG1/ERdj4 promoter region, to which XBP1 specifically binds in response to ER stress. Our results reveal a target sequence for the IRE1-XBP1 pathway under ER stress conditions. |
