| First Author | Romer J | Year | 2005 |
| Journal | Cancer Res | Volume | 65 |
| Issue | 12 | Pages | 4975-8 |
| PubMed ID | 15958535 | Mgi Jnum | J:99387 |
| Mgi Id | MGI:3582091 | Doi | 10.1158/0008-5472.CAN-05-0481 |
| Citation | Romer J, et al. (2005) Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res 65(12):4975-8 |
| abstractText | Medulloblastoma is the most common malignant pediatric brain tumor for which no satisfactory treatments exist. The Sonic Hedgehog signaling pathway seems to play an important role in the pathology of this disease. Here we review our recent demonstration that a small-molecule inhibitor of this pathway can regress tumors that arise in a transgenic mouse model of medulloblastoma. These and other findings suggest that inhibitors of Sonic Hedgehog signaling may offer an effective way to target some malignancies. |
