| First Author | Fujimura S | Year | 2005 |
| Journal | Cancer Res | Volume | 65 |
| Issue | 13 | Pages | 5925-34 |
| PubMed ID | 15994971 | Mgi Jnum | J:99522 |
| Mgi Id | MGI:3582889 | Doi | 10.1158/0008-5472.CAN-04-3259 |
| Citation | Fujimura S, et al. (2005) Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis. Cancer Res 65(13):5925-34 |
| abstractText | Lymphomas arise containing abnormalities of various differentiation stage-specific molecules. In the study reported here, we have shown abnormal up-regulation of germinal center B cell-associated GANP in various human lymphomas including mantle cell, diffuse large B cell, and Hodgkin lymphoma, by immunohistochemical analysis. To study the role of GANP in lymphomagenesis, we generated mutant mice (ganp-Tg) that express the transgenic ganp gene under immunoglobulin enhancer and promoter control. Ganp-Tg mice showed a high incidence of lymphomagenesis (29.5%) after aging with a non-B/non-T cell surface phenotype having slight CD45R/B220 expression and Ig transcripts of rearranged VH-DH-JH IgH loci. Lymphomas generated in ganp-Tg mice displayed similar pathologic characteristics to mouse reticulum cell neoplasm or Hodgkin lymphoma-like lesions. The VH sequences of individual mice showed that the tumors proliferated from a single clone or oligoclones, as is found in human diffuse large B-cell lymphomas and Hodgkin lymphoma. These results suggest that GANP overexpression is a causative factor in the generation of B lymphomas. |
