| First Author | Jimi E | Year | 2005 |
| Journal | Int Immunol | Volume | 17 |
| Issue | 6 | Pages | 815-25 |
| PubMed ID | 15908447 | Mgi Jnum | J:99532 |
| Mgi Id | MGI:3582899 | Doi | 10.1093/intimm/dxh263 |
| Citation | Jimi E, et al. (2005) Activation of NF-{kappa}B promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol 17(6):815-25 |
| abstractText | The regulation of the transcription factor nuclear factor-kappaB (NF-kappaB) during B-cell development was examined using cells isolated from the bone marrow of transgenic mice expressing a kappaB luciferase reporter gene. The results indicate that the highest level of NF-kappaB activity is present in cells expressing the pre-B-cell receptor. Furthermore, cross-linking of Igbeta on CD43(+) pre-B cells is able to activate NF-kappaB in recombination-activating gene 1-deficient mice, preceding their further differentiation into CD43(-) pre-B cells. Expression of a dominant negative form of IkappaBalpha using a transgenic approach or by retroviral infection leads to a reduction in the number of CD43(+) pre-B cells. These data therefore indicate that activation of NF-kappaB in CD43(+) pre-B cells, as a result of signaling by the pre-B-cell receptor, facilitates the continued development of large, CD43(+) pre-B cells into small CD43(-) pre-B cells. |
