| First Author | Takai T | Year | 2005 |
| Journal | Immunology | Volume | 115 |
| Issue | 4 | Pages | 433-40 |
| PubMed ID | 16011512 | Mgi Jnum | J:99753 |
| Mgi Id | MGI:3583721 | Doi | 10.1111/j.1365-2567.2005.02177.x |
| Citation | Takai T (2005) Paired immunoglobulin-like receptors and their MHC class I recognition. Immunology 115(4):433-40 |
| abstractText | The immunoglobulin-like receptors provide positive and negative regulation of immune cells upon recognition of various ligands, thus enabling those cells to respond properly to extrinsic stimuli. Murine paired immunoglobulin-like receptor (PIR)-A and PIR-B, a typical receptor pair of the immunoglobulin-like receptor family, are expressed on a wide range of cells in the immune system, such as B cells, mast cells, macrophages and dendritic cells, mostly in a pair-wise fashion. The PIR-A requires the homodimeric Fc receptor common gamma chain for its efficient cell-surface expression and for the delivery of an activation signal. In contrast, PIR-B inhibits receptor-mediated activation signals in vitro upon engagement with other activating-type receptors, such as the antigen receptor on B cells and the high-affinity Fc receptor for immunoglobulin E on mast cells. Recent identification of major histocompatibility complex (MHC) class I molecules as the physiological ligands for PIR has enabled us to attribute various immunological phenotypes observed in PIR-B-deficient mice to the consequences of the absence of a balanced interaction between PIR and MHC class I molecules expressed ubiquitously. Thus, PIR-A and PIR-B constitute a novel and physiologically important MHC class I recognition system. |
