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Publication : Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.

First Author  Aasheim HC Year  2005
Journal  Biochim Biophys Acta Volume  1723
Issue  1-3 Pages  1-7
PubMed ID  15777695 Mgi Jnum  J:100045
Mgi Id  MGI:3586420 Doi  10.1016/j.bbagen.2005.01.011
Citation  Aasheim HC, et al. (2005) Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Biochim Biophys Acta 1723(1-3):1-7
abstractText  In mammals, 14 members of the Eph receptor tyrosine kinase family have been described so far. Here we present a not yet described member of this family denoted EphA10. We report the identification of three putative EphA10 isoforms: one soluble and two transmembrane isoforms. One of the latter isoforms lacked the sterile alpha motif commonly found in Eph receptors. The gene encoding EphA10 is located on chromosome 1p34 and expression studies show that EphA10 mRNA is mainly expressed in testis. Binding studies to ephrin ligands suggests that this receptor belongs to the EphA subclass of Eph receptors binding mainly to ephrin-A ligands.
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