| First Author | Zanoni I | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 1 | Pages | 286-92 |
| PubMed ID | 15972660 | Mgi Jnum | J:100576 |
| Mgi Id | MGI:3588896 | Doi | 10.4049/jimmunol.175.1.286 |
| Citation | Zanoni I, et al. (2005) TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. J Immunol 175(1):286-92 |
| abstractText | Dendritic cells (DCs) have an important role in the activation of NK cells that exert direct antitumor and antimicrobial effects and can influence the development of adaptive T cell responses. DCs acquire NK cell stimulatory capacity after exposure to various stimuli. In this study we investigated the nature of the stimuli that confer to DCs the NK cell-activating capacity. After exposure of DCs to TLR-dependent and -independent microbial stimuli and to nonmicrobial stimuli, we evaluated the ability of activated DCs to elicit IFN-gamma production from NK cells in vitro and to promote NK cell activation in vivo. We show in this study that only TLR-dependent microbial stimuli typically associated with Th1 responses confer to DCs the ability to activate NK cells, whereas stimuli associated with Th2 responses do not have this property. |
