| First Author | Covert MW | Year | 2005 |
| Journal | Science | Volume | 309 |
| Issue | 5742 | Pages | 1854-7 |
| PubMed ID | 16166516 | Mgi Jnum | J:100898 |
| Mgi Id | MGI:3589954 | Doi | 10.1126/science.1112304 |
| Citation | Covert MW, et al. (2005) Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309(5742):1854-7 |
| abstractText | The activation dynamics of the transcription factor NF-kappaB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor-alpha (TNFalpha) but stable behavior when stimulated by lipopolysaccharide (LPS). LPS binding to Toll-like receptor 4 (TLR4) causes activation of NF-kappaB that requires two downstream pathways, each of which when isolated exhibits damped oscillatory behavior. Computational modeling of the two TLR4-dependent signaling pathways suggests that one pathway requires a time delay to establish early anti-phase activation of NF-kappaB by the two pathways. The MyD88-independent pathway required Inferon regulatory factor 3-dependent expression of TNFalpha to activate NF-kappaB, and the time required for TNFalpha synthesis established the delay. |
