| First Author | Leutner S | Year | 2000 |
| Journal | Neurosci Lett | Volume | 292 |
| Issue | 2 | Pages | 87-90 |
| PubMed ID | 10998555 | Mgi Jnum | J:101789 |
| Mgi Id | MGI:3605192 | Doi | 10.1016/s0304-3940(00)01449-x |
| Citation | Leutner S, et al. (2000) Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations. Neurosci Lett 292(2):87-90 |
| abstractText | Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1 mutations showed a significantly decreased activity of the antioxidant enzymes Cu/Zn superoxide dismutase and glutathione reductase already at an age of 3-4 months. As expected, this effect was less pronounced for the mice with a single PS1 mutation. By contrast, animals bearing normal human PS1 showed significantly elevated enzyme activities relative to non-transgenic littermate controls. |
