| First Author | Wang JP | Year | 2005 |
| Journal | J Virol | Volume | 79 |
| Issue | 20 | Pages | 12658-66 |
| PubMed ID | 16188968 | Mgi Jnum | J:101814 |
| Mgi Id | MGI:3605217 | Doi | 10.1128/JVI.79.20.12658-12666.2005 |
| Citation | Wang JP, et al. (2005) Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol 79(20):12658-66 |
| abstractText | The pattern recognition receptor Toll-like receptor 2 (TLR2) has been implicated in the response to several human viruses, including herpes simplex viruses (types 1 and 2) and cytomegalovirus. We demonstrated that varicella-zoster virus (VZV) activates inflammatory cytokine responses via TLR2. VZV specifically induced interleukin-6 (IL-6) in human monocytes via TLR2-dependent activation of NF-kappaB, and small interfering RNA designed to suppress TLR2 mRNA reduced the IL-6 response to VZV in human monocyte-derived macrophages. Unlike other herpesviruses, the cytokine response to VZV was species specific. VZV did not induce cytokines in murine embryonic fibroblasts or in a mouse cell line, although VZV did activate NF-kappaB in a human cell line expressing a murine TLR2 construct. Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection. |
