| First Author | Grass S | Year | 2003 |
| Journal | Eur J Neurosci | Volume | 17 |
| Issue | 9 | Pages | 1829-32 |
| PubMed ID | 12752782 | Mgi Jnum | J:102217 |
| Mgi Id | MGI:3607066 | Doi | 10.1046/j.1460-9568.2003.02623.x |
| Citation | Grass S, et al. (2003) Reduced spinal cord sensitization to C-fibre stimulation in mice over-expressing galanin. Eur J Neurosci 17(9):1829-32 |
| abstractText | The neuropeptide galanin may have a role in spinal nociception. In this study, we examined the excitability of the flexor reflex and its sensitization by repetitive stimulation of nociceptive C-fibres in anaesthetized mice that over-express galanin. No difference was seen between over-expressing galanin and wild-type mice in the magnitude of the baseline flexor reflex. Repetitive conditioning stimulation of C-fibres (10 stimuli at 1 Hz) produced a gradual increase in reflex magnitude during the conditioning stimulation (wind-up), as well as an increase in spinal reflex excitability after the termination of the stimulus train (central sensitization) in wild-type mice. Although the wind-up did not differ between over-expressing galanin and wild-type mice, the magnitude of central sensitization was significantly reduced in the over-expressing galanin mice (24 +/- 13% peak increase compared with 164 +/- 65% in the wild-type). Intrathecal administration of M35, a galanin receptor antagonist, markedly enhanced central sensitization in over-expressing galanin mice in association with C-fibre conditioning stimulation, while having no effect in wild-type mice. These results provide further electrophysiological evidence for an inhibitory function of galanin in modulation of central sensitization in response to C-fibre stimulation. |
