| First Author | Suzuki Y | Year | 2005 |
| Journal | Anat Rec A Discov Mol Cell Evol Biol | Volume | 286 |
| Issue | 1 | Pages | 841-7 |
| PubMed ID | 16047381 | Mgi Jnum | J:103255 |
| Mgi Id | MGI:3609005 | Doi | 10.1002/ar.a.20219 |
| Citation | Suzuki Y (2005) Role of IGFBPs in the morphogenesis of lingual papillae. Anat Rec A Discov Mol Cell Evol Biol 286(1):841-7 |
| abstractText | The expression of insulin-like growth factor binding proteins (IGFBPs) during the morphogenesis of lingual papillae of mice was examined by in situ hybridization. Among seven mouse IGFBPs, IGFBP-1, -6, and -7 mRNAs were not expressed in the tongue tissue. At E12, though no papillae have formed yet, IGFBP-2, -4, and -5 were expressed in the entire tongue epithelium. At E14, fungiform papillae appeared in the anterior region and circumvallate papillae were distinguished in the posterior region. Strong expression of IGFBP-5 was observed in the apical region of both fungiform and circumvallate papillae. At this stage, the epithelial elevation of filiform papillae was not clear; but IGFBP-5 was expressed in the apex. At E15, foliate papillae were distinguished and IGFBP-5 was expressed in the dorsal epithelium of ridges. In filiform papillae, IGFBP-3 was expressed in the core of the connective tissue. At E17, the expression of IGFBP-5 disappeared from the apical region of fungiform, filiform, foliate, and circumvallate papillae, whereas that of IGFBP-2 remained. This finding suggests that IGFBP-5 and -2 function to cause evagination of the epithelium into a raised structure. In the epithelium of trenches of foliate and circumvallate papillae, strong expression of IGFBP-4 was observed at E15 and E17. As previously suggested from a study on postnatal mice (Suzuki et al. J Comp Neurol 2005;482:74-84), IGFBP-4 acts in the epithelial invagination to form the trenches, grooves, or furrows of lingual papillae during development. |
