| First Author | Jiménez A | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 3 | Pages | 960-7 |
| PubMed ID | 16438969 | Mgi Jnum | J:105557 |
| Mgi Id | MGI:3615848 | Doi | 10.1016/j.febslet.2006.01.025 |
| Citation | Jimenez A, et al. (2006) Characterization of human thioredoxin-like-1: potential involvement in the cellular response against glucose deprivation. FEBS Lett 580(3):960-7 |
| abstractText | The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosolic selenoprotein TrxR-1. In situ hybridization experiments demonstrates high expression of Txl-1 mRNA in various areas of central nervous system and also in some reproductive organs. Glucose deprivation, but not hydrogen peroxide treatment, reduced the levels of endogenous TXL-1 protein in HEK-293 cell line. Conversely, overexpression of TXL-1 protects against glucose deprivation-induced cytotoxicity. Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress. |
