| First Author | Fukumasu H | Year | 2006 |
| Journal | Cancer Lett | Volume | 233 |
| Issue | 1 | Pages | 158-64 |
| PubMed ID | 15885883 | Mgi Jnum | J:106233 |
| Mgi Id | MGI:3617917 | Doi | 10.1016/j.canlet.2005.03.007 |
| Citation | Fukumasu H, et al. (2006) Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis. Cancer Lett 233(1):158-64 |
| abstractText | Guarana (Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guarana presented inhibitory effects on DEN hepatocarcinogenesis in mice. |
