| First Author | Letiembre M | Year | 2005 |
| Journal | J Neuroimmunol | Volume | 168 |
| Issue | 1-2 | Pages | 21-33 |
| PubMed ID | 16137770 | Mgi Jnum | J:106407 |
| Mgi Id | MGI:3618452 | Doi | 10.1016/j.jneuroim.2005.06.016 |
| Citation | Letiembre M, et al. (2005) Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol 168(1-2):21-33 |
| abstractText | TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of TLR2 and of the comolecules CD14, MD-2, TLR1/6 strongly increased and colocalized with TNF in CD45-positive infiltrating cells in the ventricles, corpus callosum and the meninges. TNF gene and protein expression was stronger in TLR2(-/-) than wt brains and associated with increased IkappaB expression suggesting that TLR2 is controlling inflammation via TNF regulation. |
