| First Author | Matsugo S | Year | 2000 |
| Journal | Neurosci Lett | Volume | 278 |
| Issue | 1-2 | Pages | 105-8 |
| PubMed ID | 10643812 | Mgi Jnum | J:107937 |
| Mgi Id | MGI:3622572 | Doi | 10.1016/s0304-3940(99)00907-6 |
| Citation | Matsugo S, et al. (2000) Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice. Neurosci Lett 278(1-2):105-8 |
| abstractText | The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8. |
