| First Author | Ventura JJ | Year | 2006 |
| Journal | Mol Cell | Volume | 21 |
| Issue | 5 | Pages | 701-10 |
| PubMed ID | 16507367 | Mgi Jnum | J:108006 |
| Mgi Id | MGI:3622847 | Doi | 10.1016/j.molcel.2006.01.018 |
| Citation | Ventura JJ, et al. (2006) Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 21(5):701-10 |
| abstractText | Exposure of primary murine embryonic fibroblasts to tumor necrosis factor (TNF) causes biphasic activation of the c-Jun NH(2)-terminal kinase (JNK) signaling pathway. The early phase (30 min) of the response to TNF is a large and transient increase in JNK activity. This response is followed by a second and more sustained phase of JNK activation that lasts many hours. We employed a chemical genetic strategy to dissect the functional consequences of these two phases of JNK activation. We report that both the early and late phases of JNK activation contribute to TNF-induced gene expression. In contrast, the early transient phase of JNK activation (<1 hr) can signal cell survival, while the later and more sustained phase of JNK activation (1-6 hr) can mediate proapoptotic signaling. These data indicate that the time course of JNK signaling can influence the biological response to JNK activation. |
