| First Author | Osmers I | Year | 2006 |
| Journal | Mol Immunol | Volume | 43 |
| Issue | 10 | Pages | 1722-5 |
| PubMed ID | 16310250 | Mgi Jnum | J:108114 |
| Mgi Id | MGI:3623051 | Doi | 10.1016/j.molimm.2005.10.004 |
| Citation | Osmers I, et al. (2006) Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated. Mol Immunol 43(10):1722-5 |
| abstractText | With the exception of a few strains such as BuB/BnJ, complement activity in most inbred strains of mice is remarkably similar. The BuB/BnJ strain reportedly has high levels of complement activity and elevated serum levels of C3 and other complement proteins. However, we observed that BuB/BnJ mice have serum C3 levels comparable to those seen in C57BL/6, Balb/c and several other strains of inbred mice. More importantly, using bacteria as a substrate for activation and deposition of complement as a direct biological assay to assess serum complement opsonic activity, we found that BuB/BnJ mice do not have elevated complement activity compared to other inbred mouse strains. In contrast hemolytic assays indicate BuB/BnJ sera to be most active. These results indicate that accepted views regarding mouse serum complement activity need to be re-examined. |
