| First Author | Ha HY | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 348 |
| Issue | 2 | Pages | 450-8 |
| PubMed ID | 16890203 | Mgi Jnum | J:111927 |
| Mgi Id | MGI:3655169 | Doi | 10.1016/j.bbrc.2006.07.079 |
| Citation | Ha HY, et al. (2006) Inhibition of the TPA-induced cutaneous inflammation and hyperplasia by EC-SOD. Biochem Biophys Res Commun 348(2):450-8 |
| abstractText | This study reports the roles of extracellular superoxide dismutase (EC-SOD) in the cutaneous inflammation and hyperplasia with 12-O-tetradecanoylphorbol-3-acetate (TPA) application in EC-SOD transgenic mice (Tg EC-SOD). Topical double TPA treatment induced the various inflammatory changes including the epidermal thickness, elevated the PCNA-labeling index, the edema formation, and increased production of hydrogen peroxide (H2O2) in wild type mice (WT). These changes were markedly suppressed in TPA-treated Tg EC-SOD. The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT. The expression of IL-1alpha was significantly increased in the skin of TPA-treated WT, especially in the basal and suprabasal layers, but it was restricted focally in basal layer of the skin of TPA-treated Tg EC-SOD. The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT. The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated. |
