| First Author | Huse M | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 3 | Pages | 247-55 |
| PubMed ID | 16444260 | Mgi Jnum | J:112595 |
| Mgi Id | MGI:3662816 | Doi | 10.1038/ni1304 |
| Citation | Huse M, et al. (2006) T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol 7(3):247-55 |
| abstractText | Activated T helper cells produce many cytokines, some of which are secreted through the immunological synapse toward the antigen-presenting cell. Here we have used immunocytochemistry, live-cell imaging and a surface-mediated secretion assay to show that there are two cytokine export pathways in T helper cells. Some cytokines, including interleukin 2 and interferon-gamma, were secreted into the synapse, whereas others, including tumor necrosis factor and the chemokine CCL3 (MIP-1alpha), were released multidirectionally. Each secretion pathway was associated with different trafficking proteins, indicating that they are molecularly distinct processes. These data suggest that T helper cells release some cytokines into the immunological synapse to impart specific communication and others multidirectionally to promote inflammation and to establish chemokine gradients. |
