| First Author | Chan IT | Year | 1993 |
| Journal | Science | Volume | 261 |
| Issue | 5128 | Pages | 1581-4 |
| PubMed ID | 8372352 | Mgi Jnum | J:113009 |
| Mgi Id | MGI:3664187 | Doi | 10.1126/science.8372352 |
| Citation | Chan IT, et al. (1993) Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association. Science 261(5128):1581-4 |
| abstractText | The CD8 alpha cytoplasmic domain associates with p56lck, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8 alpha-Lck association in T cell development was tested with transgenic mice generated to express a CD8 alpha molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8 alpha with Lck. The CD8 alpha mutant was analyzed in a CD8-/- background and in the context of the transgenic 2C T cell receptor. The development and function of CD8+ T cells in these mice were apparently normal. Thus, CD8 alpha-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function. |
