| First Author | Schiavon E | Year | 2006 |
| Journal | J Biol Chem | Volume | 281 |
| Issue | 29 | Pages | 20326-37 |
| PubMed ID | 16702217 | Mgi Jnum | J:114868 |
| Mgi Id | MGI:3690275 | Doi | 10.1074/jbc.M600565200 |
| Citation | Schiavon E, et al. (2006) Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons. J Biol Chem 281(29):20326-37 |
| abstractText | Resurgent currents are functionally crucial in sustaining the high frequency firing of cerebellar Purkinje neurons expressing Na(v)1.6 channels. Beta-scorpion toxins, such as CssIV, induce a left shift in the voltage-dependent activation of Na(v)1.2 channels by 'trapping' the IIS4 voltage sensor segment. We found that the dangerous Cn2 beta-scorpion peptide induces both the left shift voltage-dependent activation and a transient resurgent current only in human Na(v)1.6 channels (among 1.1-1.7), whereas CssIV did not induce the resurgent current. Cn2 also produced both actions in mouse Purkinje cells. These findings suggest that only distinct beta-toxins produce resurgent currents. We suggest that the novel and unique selectivity of Cn2 could make it a model drug to replace deep brain stimulation of the subthalamic nucleus in patients with Parkinson disease. |
