| First Author | Schuster MB | Year | 2006 |
| Journal | Biochim Biophys Acta | Volume | 1766 |
| Issue | 1 | Pages | 88-103 |
| PubMed ID | 16616425 | Mgi Jnum | J:115871 |
| Mgi Id | MGI:3692339 | Doi | 10.1016/j.bbcan.2006.02.003 |
| Citation | Schuster MB, et al. (2006) C/EBPalpha: a tumour suppressor in multiple tissues?. Biochim Biophys Acta 1766(1):88-103 |
| abstractText | The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues. |
