| First Author | Adams CE | Year | 2006 |
| Journal | Brain Res | Volume | 1122 |
| Issue | 1 | Pages | 27-35 |
| PubMed ID | 17010324 | Mgi Jnum | J:116042 |
| Mgi Id | MGI:3692790 | Doi | 10.1016/j.brainres.2006.08.113 |
| Citation | Adams CE, et al. (2006) Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice. Brain Res 1122(1):27-35 |
| abstractText | The time course and pattern of development of hippocampal alpha7 nicotinic acetylcholine receptors is discernibly different in C3H and DBA/2 mice. In C3H mice, the alpha7 receptor is initially expressed on embryonic day 13, exhibits an increase in density in area CA1 perinatally and is characterized by a dense, diffuse band of alpha-bungarotoxin binding at the CA3/CA1 border in the adult. In contrast, the alpha7 receptor is initially expressed on embryonic day 16 in DBA/2 mice, does not exhibit a transient perinatal increase in binding density in area CA1 and is characterized by alpha-bungarotoxin binding to numerous Nissl-stained structures in CA1 lacunosum/moleculare in the adult. Currently, it is not known whether these developmental differences occur solely as a result of the different alleles of the alpha7 receptor gene (Chrna7) expressed by the two strains or whether strain-specific background factors also play a role. The present study qualitatively examines this question by comparing alpha7 receptor development in congenic mice in which the DBA/2 allele of Chrna7 has been introgressed onto a C3H genetic background and, conversely, the C3H allele of Chrna7 has been introgressed onto a DBA/2 genetic background. The data suggest that hippocampal alpha7 receptor development is controlled predominantly by a region of mouse chromosome 7 that contains the strain-specific Chrna7 allele. |
