| First Author | Nam JS | Year | 2007 |
| Journal | Gene Expr Patterns | Volume | 7 |
| Issue | 3 | Pages | 306-12 |
| PubMed ID | 17035101 | Mgi Jnum | J:116140 |
| Mgi Id | MGI:3693046 | Doi | 10.1016/j.modgep.2006.08.006 |
| Citation | Nam JS, et al. (2007) Dynamic expression of R-spondin family genes in mouse development. Gene Expr Patterns 7(3):306-12 |
| abstractText | R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Wnt signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages. |
