| First Author | Mondor I | Year | 2005 |
| Journal | Cell Death Differ | Volume | 12 |
| Issue | 11 | Pages | 1398-406 |
| PubMed ID | 15920533 | Mgi Jnum | J:116385 |
| Mgi Id | MGI:3694171 | Doi | 10.1038/sj.cdd.4401673 |
| Citation | Mondor I, et al. (2005) RelA regulates the survival of activated effector CD8 T cells. Cell Death Differ 12(11):1398-406 |
| abstractText | Nuclear factor of kappa B (NF-kappaB) transcription factors are critical regulators of T-cell activation and survival. The relative contribution of individual NF-kappaB members to these processes remains elusive. We investigated the role of RelA in the regulation of CD8 T-cell activation. We overexpressed, in mature CD8 T cells, a transactivation domain-deficient RelA molecule (p65TAD). We show that p65TAD forms homo- and heterodimers with p50 that bind kappaB sites and selectively inhibit RelA-dependent transactivation. Expression of p65TAD does not affect initial activation or cell cycle progression but induces the death of activated CD8 T cells in vitro and in vivo. However, the long-term survival of resting effector CD8 T cells seems not to be affected by p65TAD expression. Collectively, our results indicate that RelA is a critical regulator of survival of proliferating CD8 T cells but may be dispensable for the survival of resting effector T cells. |
